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J Thorac Dis. 2014 Aug;6(8):1159-63. doi: 10.3978/j.issn.2072-1439.2014.07.25.

Overview of paediatric heart-lung transplantation: a global perspective.

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 In this issue of The Journal of Thoracic Disease (JTD) Jonathon Spahr and Shawn West from the Children’s Hospital of Pittsburgh and the University of Pittsburg School of Medicine have presented a perspective on paediatric heart-lung transplantation based on data from their own institution, the Organ Procurement and Transplant Network and supported with data from the International Society for Heart and Lung Transplantation (ISHLT). They have provided a detailed and succinct overview of progress to the current era including indications, contraindications, outcomes and potential future possibilities largely based on the US experience. This editorial aims to extend the review by elaborating on the global perspective of paediatric heart-lung transplantation, particularly in relation to changes in volume and indications over the past 30 years and the influence of organ allocation policies internationally.
Arch Bronconeumol. 2013 Dec;49(12):523-8. doi: 10.1016/j.arbres.2013.09.006. Epub 2013 Nov 12.

Lung transplantation in children. Specific aspects.


Lung transplantation has become in recent years a therapeutic option for infantswith terminal lung disease with similar results to transplantation in adults.In Spain, since 1996 114 children lung transplants have been performed; this corresponds to3.9% of the total transplant number.The most common indication in children is cystic fibrosis, which represents between 70-80% of the transplants performed in adolescents. In infants common indications areinterstitial lung disease and pulmonary hypertension.In most children a sequential double lung transplant is performed, generally with the help ofextracorporeal circulation. Lung transplantation in children presents special challenges in monitoring and follow-up, especially in infants, given the difficulty in assessing lung function and performing transbronchial biopsies.There are some more specific complications in children like postransplant lymphoproliferative syndrome or a greater severity of respiratory virus infections .After lung transplantation children usually experiment a very important improvement in their quality of life. Eighty eight per cent of children have no limitations in their activity after 3 years of transplantation.According to the registry of the International Society for Heart & Lung Transplantation (ISHLT) survival at 5 years of transplantation is 54% and at 10 years is around 35%.


Children; Cystic fibrosis; Fibrosis quística; Hipertensión pulmonar; Interstitial pneumonia; Lung transplant; Neumopatías intersticiales; Niños; Pulmonary hypertension; Trasplante pulmonar


The Healthcare working group has prepared this data in order to complete the following objectives :

(1) Defining healthcare resources available in every Transplanchild member center including all transplantations active programs, for providing the best healthcare to cases that could eventually require Transplanchild for care.
(2) Focus on high-complex diagnostic methods/techniques , therapeutical procedures and specific transplantation models / variants, accepted for clinical practice but not every center/program might dispose at this moment.
(3) Looking for every center areas of experience / expertise / knowledge to take advantage of it for providing the best healthcare for the clinical cases that required it.


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